بررسی جنبه های اپیدمیولوژیک و پاتولوژیک لیپوسارکوم در بیمارستان های دانشگاهی شهر مشهد در طی ده سال

Background and Aim: Liposarcoma is one of the most common soft tissue sarcomas in adults, ranging in incidence from 9.8% to 16%, which is recognized through the presence of lipoblast cells. It reaches its peak incidence during the fifth and seventh decades of life in males. It develops predominantly in the lower extremity and retroperitoneum; also, there are some other uncommon localizations as well. Classification of liposarcoma is based on five histologic categories that generally reflect the degree of differentiation including well- differentiated, myxoid, round cell, differentiated, and pleomorphic liposarcoma. The present study was aimed at evaluating parameters such as age, sex, localization, and approximate incidence of liposarcoma among patients in three University Medical Centers in Mashhad. Materials and Methods: In this retrospective study of 10 years (1992-2002), all specimens sent to pathology laboratories, Imam Reza specialized clinic, Imam Reza and Ghaem hospitals; plus all soft tissue sarcoma samples- which diagnosed as liposarcoma were reviewed statistically. Results: Among 115 (0.12% of all specimens of soft tissue sarcoma) 26 (25%) items were liposarcoma (16males, 10 females). Patients' age ranged between 16 and 77 years; mostly between 40 and 49. The most commonly site was lower extremity; and uncommon localizations were mediastinum, posterior of tongue, nasopharynx , labia majora, and esophagus. Histologically, the most common subtype and predominant pattern of liposarcoma was myxoid. Conclusion: On the basis of this study, Liposarcoma is a relatively common neoplasm in our region. Regarding the possibility of liposarcoma incidence in any site of the body, it is recommended to think of liposarcoma in your differential diagnoses when you observe a mass having cells similar to lipoblasts. Besides, since histological subtype is the most important prognostic factor, it is better to classify liposarcoma as far as possible. Because some samples represent a combination of two or three kinds (mixed typeliposarcoma), multiple sampling from different sites of the tumor is recommended.